2 Postdoc Positions available: 1 Computational Biologist and 1 Molecular Biologist non-coding RNA & R-loop epigenetics

2 Postdoc Positions available: 1 Computational Biologist and 1 Molecular Biologist non-coding RNA & R-loop epigenetics

Anbieterbeschreibung: 

The Institute of Molecular Biology gGmbH (IMB) is a Centre of Excellence for Life Sciences, funded by the Boehringer Ingelheim Foundation. It is located within the campus of the Johannes Gutenberg-University, Mainz, Germany. The Niehrs laboratory studies regulation of DNA methylation, which plays important roles in development & disease. We have recently demonstrated a role for long non-coding RNAs and R-loop DNA:RNA hybrids in DNA methylation (Arab et al. 2014, Mol Cell, (2014) 55: 604-614).  In an ERC-funded project, we now aim to elucidate the mechanisms of DNA demethylation as well as the role played by long non-coding RNAs and R-loops in its regulation. See also  www.imb-mainz.de/research-at-imb/niehrs/research/

Stellenbeschreibung: 

The candidates will make use of mouse embryonic stem cells (ESCs) to interrogate genome-wide the role of ncRNAs and R-loops in targeting GADD45a and the DNA demethylation machinery in the genomee will use CRISPR/CAS9 mediated ESC mutants, as well as ChIP-seq, RNA-seq, bisulfite-seq to carry out multi- dimensional data analysis to address: Where in the genome does demethylation occur? What are the molecular determinants in ncRNA & Rloops involved in targeting? What are the cofactors involved? The project will involve strong interaction between the Molecular- and the Computational Biologist.

Anforderungsprofil 

  • PhD & publications in a relevant field
  • Sound experience in R scripting or Python (Computational Biologist)
  • Sound experience in molecular biology (Molecular Biologist)
  • Familiarity with Omics techniques or –analysis, or with ncRNAs or R-loops is advantageous
  • Excellent communication skills and good team spirit with the ability to solve problems independently
  • Fluent in English (spoken and written)
Weitere Informationen: 

We offer

• An international and vibrant working environment

• Competitive salary

• Training opportunities

• Favourable pension scheme

 

To apply please send a single PDF file containing your cover letter stating research and career interests, CV, scans of your degrees (Germans: including copies of Abitur- & Diplom/Master Zeugnis), and contact details of 2 references to personnel@imb-mainz.de. Informal enquires should be addressed to Prof. Christof Niehrs (c.niehrs@imb-mainz.de).

 

Starting date: before April 2018

Duration: Initially 3 years; option for further extension

Application Deadline: 31st December 2018

Declaration of Consent and Data Protection

By sending us your application, you are consenting to us saving your personal data in order to carry out the selection process. You can find more information on data protection and retention periods at https://www.imb.de/jobs/datenschutzerklaerung-data-protection/

22. Okt 2018

Stellenbezeichnung 

  • 2 Postdoc Positions available: 1 Computational Biologist and 1 Molecular Biologist non-coding RNA & R-loop epigenetics

Bewerbungsfrist 

  • Montag, 31. Dezember 2018

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